| 2026年 | Suzuki T, Heishima K, Yamazaki J, Yamazaki M, Kinoshita R, Kim S, Hosoya K, Okamatsu-Ogura Y, Sasaki M, Xu P, Yan Q, Kimura T, Aoshima K. Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma. Front Vet Sci. 2026;13:1734339. |
| Miki S, Hosoya K, Sasaki N, Kinoshita R, Owaki R, Kim S, Okumura M. Restoration of hepatopetal portal flow in a cat with left hepatic arteriovenous malformation following left hepatic division resection and staged attenuation of acquired portosystemic shunts. J Vet Med Sci. In Press. |
| 2025年 | Matsumoto S, Hosoya K, Kojima K, Takeuchi K, Kinoshita R, Kim S, Okumura M. Xenotransfusion of canine packed red blood cells to a cat for emergency treatment of acute hemorrhage after thymectomy. Jpn J Vet Anesth Surg. 2025;56:44-50. |
| Takeuchi K, Hosoya K, Owaki R, Kinoshita R, Kim S, Okumura M. Successful surgical removal of a retroperitoneal paraganglioma in the celiac artery trifurcation in a dog. BMC Vet Res. 2025;21:651. |
| Takagi S, Tagawa M, Maekawa N, Konnai S, Kagawa Y, Hosoya K, Yamauchi A, Kudo A, Kamo S, Kim S, Kinoshita R, Deguchi T, Owaki R, Tachibana Y, Yokokawa M, Takeuchi H, Nakamura H, Kato Y, Kanazawa S, Abe T, Furuta T, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K. Clinical efficacy of anti-programmed death ligand 1 antibody HFC-L1/c4G12 in dogs with malignant tumors: an exploratory study. J Vet Med Sci. 2025;87:1419-1425. |
| Hosoya K, Kim S, Kinoshita R, Maekawa N, Konnai S, Takagi S, Tagawa M, Kagawa Y, Deguchi T, Owaki R, Tachibana Y, Yokokawa M, Takeuchi H, Nakamura H, Yamauchi A, Kudo A, Kamo S, Kato Y, Kanazawa S, Abe T, Furuta T, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K. Exploratory, randomized, dose-response study of the anti-PD-L1 antibody HFC-L1/c4G12 in dogs with pulmonary metastatic oral malignant melanoma. Vet Sci. 2025;12:850. |
| Fukuyama Y, Hosoya K, Kim S, Sung K, Deguchi T, Shimbo G, Sasaoka K, Kinoshita R, Takiguchi M. Outcomes and prognostic factors in dogs with presumed intracranial gliomas treated with definitive-intent intensity modulated radiation therapy: 55 cases (2014-2023). Vet Comp Oncol. 2025;23:616-628. |
| Maekawa N, Konnai S, Watari K, Takeuchi H, Nakanishi T, Tachibana T, Hosoya K, Kim S, Kinoshita R, Owaki R, Yokokawa M, Kagawa Y, Takagi S, Deguchi T, Ohta H, Kato Y, Yamamoto S, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K. Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs. Front Immunol. 2025;16:1570717. |
| Sung K, Hosoya K, Deguchi T, Yamashita K, Kim S, Sunaga T, Yasui H, Inanami O, Okumura M. Glutathione-associated redox regulation alleviates radio-resistance of canine cancer stem-like cells with low proteasome activity. Sci Rep. 2025;15:18017. |
| Owaki R, Hosoya K, Deguchi T, Konnai S, Maekawa N, Okagawa T, Yasui H, Kim S, Sunaga T, Okumura M. Enhancement of radio-sensitivity by inhibition of Janus kinase signaling with oclacitinib in canine tumor cell lines. Mol Ther Oncol. 2025;33:200946. |
| 2024年 | Sasaoka K, Sato T, Morishita K, Hosoya K, Yokoyama N, Sato T, Horiuchi M, Takiguchi M. Antimicrobial resistance and self-reported hand hygiene awareness before and after an infection prevention and control programme: a 7-year analysis in a small animal veterinary teaching hospital. Vet J. 2024;306:106154. |
| Nagata N, Sawamura H, Ikenaka Y, Morishita K, Hosoya K, Sasaki N, Nakamura K, Takiguchi M. Urinary steroid profiling using liquid chromatography-tandem mass spectrometry for the diagnosis of canine Cushing’s syndrome. Vet J. 2024;306:106151. |
| 2023年 | Maekawa N, Konnai S, Hosoya K, Kim S, Kinoshita R, Deguchi T, Owaki R, Tachibana Y, Yokokawa M, Takeuchi H, Kagawa Y, Takagi S, Ohta H, Kato Y, Yamamoto S, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K. Safety and clinical efficacy of an anti-PD-L1 antibody (c4G12) in dogs with advanced malignant tumours. PLoS One. 2023;18:e0291727. |
| Asari Y, Yamazaki J, Thandar O, Suzuki T, Aoshima K, Takeuchi K, Kinoshita R, Kim S, Hosoya K, Ishizaki T, Kagawa Y, Jelinek J, Yokoyama S, Sasaki N, Ohta H, Nakamura K, Takiguchi M. Diverse genome-wide DNA methylation alterations in canine hepatocellular tumours. Vet Med Sci. 2023;9:2006-2014. |
| Deguchi T, Maekawa N, Konnai S, Owaki R, Hosoya K, Morishita K, Nakamura M, Okagawa T, Takeuchi H, Kim S, Kinoshita R, Tachibana Y, Yokokawa M, Takagi S, Kato Y, Suzuki Y, Murata S, Ohashi K. Enhanced systemic antitumour immunity by hypofractionated radiotherapy and anti-PD-L1 therapy in dogs with pulmonary metastatic oral malignant melanoma. Cancers. 2023;15:3013. |
| Kanemoto H, Fujiwara-Igarashi A, Kobayashi T, Harada K, Ichimata M, Kim S, Hosoya K, Tomiyasu H, Ohmi A, Tsujimoto H. Retrospective study of feline tracheal mass lesions. J Feline Med Surg. 2023;25:1098612X231164611. |
| Sugawara-Suda M, Morishita K, Ichii O, Namba T, Aoshima K, Kagawa Y, Kim S, Hosoya K, Yokoyama N, Sasaki N, Nakamura K, Yamazaki J, Takiguchi M. Transcriptome and proteome analysis of dogs with precursor targeted immune-mediated anemia treated with splenectomy. PLoS One. 2023;18:e0285415. |
| Owaki R, Deguchi T, Konnai S, Maekawa N, Okagawa T, Hosoya K, Kim S, Sunaga T, Okumura M. Regulation of programmed death ligand 1 expression by interferon-γ and tumour necrosis factor-α in canine tumour cell lines. Vet Comp Oncol. 2023;21:279-290. |
| 2022年 | Maekawa N, Konnai S, Asano Y, Sajiki Y, Deguchi T, Okagawa T, Watari K, Takeuchi H, Takagi S, Hosoya K, Kim S, Ohta H, Kato Y, Suzuki Y, Murata S, Ohashi K. Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy. Sci Rep. 2022;12:9265. |
| Nagata N, Sawamura H, Morishita K, Hosoya K, Yokoyama N, Sasaoka K, Sasaki N, Nakamura K, Ikenaka Y, Takiguchi M. Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism. J Vet Med Sci. 2022;84:954-959. |
| Tamura M, Ohta H, Hasegawa N, Hosoya K, Takiguchi M. Case report: usefulness of drip infusion cholangiography with computed tomography for the diagnosis of biloma in a dog. Front Vet Sci. 2022;9:854042. |
| Takagi S, Nishino A, Hanazono K, Hosoya K. Computed angiographic variations in hepatic venous vasculature in dogs. Vet Surg. 2022;51:631-637. |
| Murase Y, Hosoya K, Sato T, Kim S, Okumura M. Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells. Oncol Rep. 2022;47:61. |
| Hoshi K, Hosoya K, Takagi S, Kim S, Okumura M. Direct renal pelvicocystostomy using tube cystoplasty in a dog with a complete ureteral obstruction. J Small Anim Pract. 2022;63:635-641. |
| Sung K, Hosoya K, Murase Y, Deguchi T, Kim S, Sunaga T, Okumura M. Visualizing the cancer stem-like properties of canine tumour cells with low proteasome activity. Vet Comp Oncol. 2022;20:324-335. |
| 2021年 | Takeuchi R, Takagi S, Hosoya K, Ohta H, Itami T, Okumura M. Postoperative improvement of megaesophagus and esophageal motility in a 19-day-old puppy with gastroesophageal intussusception. J Vet Med Sci. 2021;83:1740-1744. |
| Deguchi T, Hosoya K, Kim S, Murase Y, Yamamoto K, Bo T, Yasui H, Inanami O, Okumura M. Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS. Mol Ther Oncolytics. 2021;22:143-151. |
| Kim S, Hosoya K, Fukayama N, Deguchi T, Okumura M. Safety and efficacy of a nonmyeloablative pretransplant conditioning regimen using total lymphoid irradiation with volumetric modulated arc therapy in healthy dogs: a pilot study. Vet Med Sci. 2021;7:1120-1130. |
| Maekawa N, Konnai S, Nishimura M, Kagawa Y, Takagi S, Hosoya K, Ohta H, Kim S, Okagawa T, Izumi Y, Deguchi T, Kato Y, Yamamoto S, Yamamoto K, Toda M, Nakajima C, Suzuki Y, Murata S, Ohashi K. PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma. npj Precis Oncol. 2021;5:10. |
| Tamura J, Oyama N, Matsumoto S, Owaki R, Hosoya K, Okumura M. Unrecognized difficult airway management during anesthesia in two brachycephalic dogs with narrow cricoid cartilage. J Vet Med Sci. 2021;83:234-240. |
| 2020年 | Tsogbadrakh M, Sunaga T, Bwalya E, Wijekoon S, Akaraphutiporn E, Wang Y, Mwale C, Naranbaatar A, Kim S, Hosoya K, Alimaa D, Okumura M. Clinical evaluation of pentosan polysulfate as a chondroprotective substance in native Mongolian horses. Jpn J Vet Res. 2020;68:203-208. |
| Takagi S, Takeuchi K, Hosoya K, Hoshino Y, Kim S, Itami T, Yamane Y, Hanazono K. Surgical removal of an obstructive sialolith from the parotid duct opening using an intraoral approach while preserving the parotid gland in a dog. J Jpn Vet Med Assoc. 2020;73:379-382. |
| Takagi S, Yamazaki H, Izumi Y, Hanazono K, Hoshino Y, Hosoya K. Assessment of tumor enhancement by contrast-enhanced CT in solid tumor-bearing dogs treated with toceranib phosphate. Vet Radiol Ultrasound. 2020;61:427-434. |
| 2019年 | Kim S, Hosoya K, Takagi S, Okumura M. Outcomes following balloon dilation for management of urethral obstruction secondary to urothelial carcinoma in dogs: 12 cases (2010-2015). J Am Vet Med Assoc. 2019;255:330-335. |
| Leela-Arporn R, Ohta H, Tamura M, Nagata N, Sasaoka K, Dermlim A, Nisa K, Morishita K, Sasaki N, Nakamura K, Takagi S, Hosoya K, Takiguchi M. Predictive factors of malignancy in dogs with focal liver lesions using clinical data and ultrasonographic features. J Vet Med Sci. 2019;81:723-729. |
| Leela-Arporn R, Ohta H, Nagata N, Sasaoka K, Tamura M, Dermlim A, Nisa K, Morishita K, Sasaki N, Nakamura K, Takagi S, Hosoya K, Takiguchi M. Epidemiology of massive hepatocellular carcinoma in dogs: a 4-year retrospective study. Vet J. 2019;248:74-78. |
| Deguchi T, Hosoya K, Murase Y, Koangyong S, Kim S, Okumura M. Analysis of radiosensitivity of cancer stem-like cells derived from canine cancer cell lines. Vet Comp Oncol. 2019;17:119-129. |
| Suranji Wijekoon HM, Kim S, Bwalya EC, Fang J, Aoshima K, Hosoya K, Okumura M. Anti-arthritic effect of pentosan polysulfate in rats with collagen-induced arthritis. Res Vet Sci. 2019;122:179-185. |
| Kim S, Hosoya K, Kobayashi A, Okumura M. Comparison of three mobilization protocols for peripheral blood stem cell apheresis with Spectra Optia continuous mononuclear cell protocol in healthy dogs. Vet Comp Oncol. 2019;17:61-68. |
| 2018年 | Bwalya EC, Wijekoon HS, Fang J, Kim S, Hosoya K, Okumura M. Independent chondrogenic potential of canine bone marrow-derived mesenchymal stem cells in monolayer expansion cultures decreases in a passage-dependent pattern. J Vet Med Sci. 2018;80:1681-1687. |
| Takagi S, Kagawa Y, Hanazono K, Murakami S, Deguchi T, Izumi Y, Hosoya K, Kim S, Okumura M. Mandibular vascular hamartoma in a cat. J Vet Med Sci. 2018;80:1456-1458. |
| Bwalya E, Kim S, Fang J, Wijekoon HMS, Hosoya K, Okumura M. Pentosan polysulfate sodium restores the phenotype of dedifferentiated monolayer canine articular chondrocytes cultured in alginate beads. J Tissue Sci Eng. 2018;9:218. |
| Wijekoon HMS, Bwalya EC, Fang J, Kim S, Hosoya K, Okumura M. Inhibitory effects of sodium pentosan polysulfate on formation and function of osteoclasts derived from canine bone marrow. BMC Vet Res. 2018;14:152. |
| 2017年 | Matsuyama A, Takagi S, Hosoya K, Kagawa Y, Nakamura K, Deguchi T, Takiguchi M. Impact of surgical margins on survival of 37 dogs with massive hepatocellular carcinoma. N Z Vet J. 2017;65:227-231. |
| Bwalya EC, Kim S, Fang J, Wijekoon HMS, Hosoya K, Okumura M. Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes. PLoS One. 2017;12:e0177144. |
| Bwalya EC, Kim S, Fang J, Wijekoon HMS, Hosoya K, Okumura M. Effects of pentosan polysulfate and polysulfated glycosaminoglycan on chondrogenesis of canine bone marrow-derived mesenchymal stem cells in alginate and micromass culture. J Vet Med Sci. 2017;79:1182-1190. |
| Wijekoon HMS, Toyota K, Kim S, Fang J, Bwalya EC, Hosoya K, Okumura M. Differentiation potential of synoviocytes derived from joints with cranial cruciate ligament rupture and medial patella luxation in dogs. Res Vet Sci. 2017;114:370-377. |
| 2015年 | Kim S, Hosoya K, Takagi S, Okumura M. Treatment of gastrin-secreting tumor with sustained-release octreotide acetate in a dog. J Am Anim Hosp Assoc. 2015;51:407-412. |
| Izumi Y, Hoshino Y, Hosoya K, et al. Isolation and characterization of canine tumor endothelial cells. J Vet Med Sci. 2015;77:359-363. |
| Yamazaki H, Takagi S, Hosoya K, et al. Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models. Res Vet Sci. 2015;99:137-144. |
| Yamazaki H, Takagi S, Hosoya K, et al. Influence of a survivin suppressor YM155 on the chemoresistance of canine histiocytic sarcoma cells. Vet J. 2015;(Epub May 8). |
| Yamazaki H, Iwano T, Otsuka S, Kagawa Y, Hoshino Y, Hosoya K, Okumura M, Takagi S. SiRNA knockdown of the DEK nuclear protein mRNA enhances apoptosis and chemosensitivity of canine transitional cell carcinoma cells. Vet J. 2015;204:60-65. |
| 2014年 | Alvarez FJ, Kisseberth W, Hosoya K, et al. Postoperative adjuvant combination therapy with doxorubicin and noncytotoxic suramin in dogs with appendicular osteosarcoma. J Am Anim Hosp Assoc. 2014;50:12-18. |
| Oh N, Kim S, Hosoya K, Okumura M. Compensatory cellular reactions to nonsteroidal anti-inflammatory drugs on osteogenic differentiation in canine bone marrow-derived mesenchymal stem cells. J Vet Med Sci. 2014;76:629-636. |
| Yamazaki H, Takagi S, Oh N, Hoshino Y, Hosoya K, Okumura M. Comparative analysis of mRNA expression of surface antigens between histiocytic and nonhistiocytic sarcoma in dogs. J Vet Intern Med. 2014;28:204-210. |
| Hosoya K, Couto CG, London CA, Kisseberth WC, Phelps MA, Dalton JT. Comparison of high-dose intermittent and low-dose continuous oral artemisinin in dogs with naturally occurring tumors. J Am Anim Hosp Assoc. 2014;50:390-395. |
| 2013年 | Hosoya K, Takagi S, Okumura M. Iatrogenic tumor seeding after ureteral stenting in a dog with urothelial carcinoma. J Am Anim Hosp Assoc. 2013;49:262-266. |
| Alvarez FJ, Hosoya K, Lara-Garcia A, Kisseberth WC, Couto CG. VAC protocol for treatment of stage III hemangiosarcoma in dogs. J Vet Intern Med. 2013;49:370-377. |
| Yamazaki H, Takagi S, Oh N, Hoshino Y, Hosoya K, Okumura M. Inhibition of survivin influences the biological activities of canine histiocytic sarcoma cell lines. PLoS One. 2013;8:e79810. |
| 2012年 | Marin LM, Iazbik MC, Zaldivar-Lopez S, Lord LK, Stingle N, Vilar P, Lara-Garcia A, Alvarez F, Hosoya K, Nelson L, Pozzi A, Cooper E, Kisseberth W, London CA, Dudley R, Dyce J, McMahon M, Lerche P, Bednarski R, Couto CG. Retrospective evaluation of the effectiveness of epsilon aminocaproic acid for the prevention of postamputation bleeding in retired racing Greyhounds with appendicular bone tumors: 46 cases (2003-2008). J Vet Emerg Crit Care. 2012;22:332-340. |
| Sunaga T, Oh N, Hosoya K, Takagi S, Okumura M. Pro-apoptotic effects of tepoxalin, a cyclooxygenase/lipoxygenase dual inhibitor, on canine synovial fibroblasts. J Vet Med Sci. 2012;74:745-750. |
| Sunaga T, Oh N, Hosoya K, Takagi S, Okumura M. Inhibitory effects of pentosan polysulfate sodium on MAP-kinase pathway and NF-κB nuclear translocation in canine chondrocytes in vitro. J Vet Med Sci. 2012;74:707-711. |
| Yamazaki H, Takagi S, Ogi N, Hosoya K, Okumura M. Urethral dilation using balloon catheters for uroschesis caused by urogenital tumors in four dogs. J Jpn Vet Med Assoc. 2012;65:530-533. |
| 2011年 | Vilar-Saavedra P, Hosoya K. Thromboelastographic profile for a dog with hypocoagulable and hyperfibrinolytic phase of disseminated intravascular coagulopathy. J Small Anim Pract. 2011;In Press. |
| 2010年 | Lin C, Hosoya K, Premanandan C, Wellman M. What is your diagnosis? Fine needle aspiration of an aggressive bone lesion from a dog. Vet Clin Pathol. 2010;39:397-398. |
| Lettry V, Sumie Y, Mitsuda K, Tagami M, Hosoya K, Takagi S, Okumura M. Divergent diagnosis from arthroscopic findings and identification of CPII and C2C for detection of cartilage degradation in horses. Jpn J Vet Res. 2010;57:197-206. |
| Lettry V, Kawasaki H, Sugaya K, Hosoya K, Takagi S, Okumura M. Evaluation of a new enzyme-linked immunosorbent assay to detect keratan sulphate in equine serum. Jpn J Vet Res. 2010;57:207-212. |
| 2009年 | Hosoya K, Kisseberth WC, Alvarez FJ, Lara-Garcia A, Beamer GL, Stromberg JP, Couto CG. Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors. J Am Anim Hosp Assoc. 2009;45:1-5. |
| Hosoya K, Lord LK, Lara-Garcia A, Kisseberth WC, London CA, Couto CG. Prevalence of elevated alanine transaminase (ALT) activity in dogs treated with CCNU (lomustine). Vet Comp Oncol. 2009;7:244-255. |
| 2008年 | Hosoya K, Murahari S, Laio A, London CA, Couto CG, Kisseberth WC. Dihydroartemisinin exhibits biologic activity against canine osteosarcoma cell lines. Am J Vet Res. 2008;69:519-526. |
| Lara-Garcia A, Hosoya K, Iazbik C, Westerndorf N, Gallant S, Couto CG. Evaluation of a point-of-care hematology analyzer for use in dogs and cats receiving chemotherapeutic treatment. J Am Vet Med Assoc. 2008;232:1488-1495. |
| Hosoya K, Poulson JM, Azuma C. Osteoradionecrosis and radiation induced bone tumors following orthovoltage radiation therapy in dogs. Vet Radiol Ultrasound. 2008;49(2):189-195. |
| 2007年 | Hosoya K, Kisseberth WC, Lord LK, Alvarez FJ, Lara-Garcia A, Kosarek CE, London CA, Couto CG. Comparison of COAP and UW-19 protocols in dogs with multicentric lymphoma. J Vet Intern Med. 2007;21(6):1355-1363. |
| Ishioka S, Hosoya K, Kitagawa H, Shibata H, Honjoh T, Kimura K, Saito M. Plasma leptin concentration in dogs: Effects of body condition score, age, gender and breeds. Res Vet Sci. 2007;83(1):5-11. |
